Effect of Bretylium and Guanethidine on the Hyperglycaemic Action of Adrenaline.
نویسندگان
چکیده
Two new antihypertensive drugs, bretylium and guanethidine have recently been introduced in therapeutics. These drugs produce a gradual, lowering of arterial blood pressure in animals and man, probably through a specific blocking action on the peripheral adrenergic neurone (Boura and Green, 1959; Maxwell et al., 1959). Guanethidine in addition causes a depletion of the tissue stores of noradrenaline (Sheppard and Zimmerman, 1959).
منابع مشابه
Effects of guanethidine and bretylium on the sweating axon reflex in human skin.
It has been known that guanethidine and bretylium possess some common pharmacological properties. The sympathetic ganglionic transmission has been reported to be blocked by guanethidine (Maxwell, Mull and Plummer;1 Maxwell, Plummer, Schneider, Povalski and Daniel;2 Bein;3 Gertner and Romano4) and also by bretylium (Boura and Green;5 Green;6 Gertner and Romano4; Shand7). However, the mode of act...
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The effect of Adrenaline 0.5 per cent and Guanethidine 2.5 per cent alone and in combination in reducing intraocular pressure in rabbits has been studied. Six rabbits were used and the efficiencies of 5 different dosage protocols was estimated both as intensity and duration of activity. The 5 dosage protocols were Adrenaline alone; Guanethidine alone; Adrenaline and Guanethidine together; Adren...
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 7 شماره
صفحات -
تاریخ انتشار 1963